20 Common Medications That Are Bad For You in the Long-Term


Antipsychotic drugs are used to treat a large variety of disorders ranging from mental health ones such as bipolar disorder or borderline personality disorder to more common health problems such as sleep or anxiety. Antipsychotic drugs are designed for people with schizophrenia, however. These drugs have limited testing available for how well they work for or whether they should be used long-term with other problems. Long-term use may result in weight gain or movement disorders. Elderly users may even be put at a higher risk for strokes.


Methotrexate, along with other chemotherapeutic agents, are dangerous in the long-term. It treats everything from arthritis to cancer, but it comes at a serious risk. It kills cells — all cells — without regard for the type of cell it is killing. It’s dangerous for pregnant women and their unborn children. It can cause fatal reactions in people also taking NSAIDs. Bone, liver, kidney, intestinal, and immune problems are all associated with this drug and its long-term usage.

Heartburn Drugs

Heartburn is extremely common. Most people will suffer from it in some way at some point during their lives. Heartburn is a misleading name, though. It’s the result of stomach acid flowing up into your esophagus, some place it’s obviously not supposed to be. Heartburn drugs function to repress your stomach acid. While this may be fine for short-term uses, long-term use will cause problems because stomach acid is crucial to our health. Add in the fact that these drugs do nothing to fix your problem, only hide it, and it leaves you wondering why you aren’t already looking for newer, better ways to manage your heartburn.


As women go through menopause, their body stops producing as much estrogen as it had up until that point. These results in a variety of problems, some of which are simply uncomfortable while others are downright dangerous. Sometimes, these women take hormone-therapy drugs to get their estrogen levels higher to relieve these problems. Long-term use of estrogen comes with plenty of documented problems, such as an increased risk of breast cancer, blood clots, and dementia.

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